Tunable photonic crystal biosensors for portable label-free diagnostics
Abstract/Contents
- Abstract
- Although there is a pressing global need for widely-deployable disease detection and monitoring systems, today's options for biochemical analysis are often bulky, slow, expensive, and reliant on trained medical personnel. In contrast, the miniaturization and integration of devices based on arrays of sources, detectors, and active or passive biosensing surfaces provides a means to achieve handheld diagnostic capabilities with a "lab-on-a-chip" that would be vastly less expensive and fully automated. In this thesis, we design, fabricate, and characterize tunable biosensors with compact and low-cost Vertical Cavity Surface Emitting Lasers (VCSELs), integrated detectors, Peltier coolers, photonic crystal slab resonators, and polymer microfluidics. All of the components utilize scalable semiconductor and soft-lithography techniques to significantly reduce the required device footprint, simplify system assembly, and enable large-scale, economical manufacturing. The sensors operate in the visible to near-infrared 650-900 nm wavelength range for low absorption of water, hemoglobin, and other background elements found in tissue or aqueous samples. Moreover, the 670 nm label-free sensors we demonstrate are designed for compatibility with previously characterized monolithically integrated fluorimeters that capitalize on emerging deep-red fluorescent proteins and molecular probes approved for pre-clinical use by the Federal Drug Administration.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2012 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Lee, Meredith Marie |
|---|---|
| Associated with | Stanford University, Department of Electrical Engineering |
| Primary advisor | Harris, J. S. (James Stewart), 1942- |
| Thesis advisor | Harris, J. S. (James Stewart), 1942- |
| Thesis advisor | Fan, Shanhui, 1972- |
| Thesis advisor | Hesselink, Lambertus |
| Advisor | Fan, Shanhui, 1972- |
| Advisor | Hesselink, Lambertus |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Meredith Marie Lee. |
|---|---|
| Note | Submitted to the Department of Electrical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2012. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2012 by Meredith Marie Lee
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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