Models to inform the safe collection and transfusion of donated blood
Abstract/Contents
- Abstract
- Donated blood is a critical component of health systems around the world, but its collection and transfusion involve risk for both donors and recipients. Transfusion-transmitted diseases and non-infectious adverse events pose a risk to transfusion recipients, and repeat blood donation can cause or exacerbate iron deficiency among donors. This dissertation describes four decision-analytic modeling projects that inform blood safety policy. In Chapter 2, I integrate epidemiological, health-economic, and biovigilance data to estimate the efficacy and cost-effectiveness of a 2016 policy mandating that all blood donations are screened for Zika virus in the U.S. The analysis uses a novel microsimulation of individual transfusion recipients that captures the relationship between disease exposure risk and the number and type of blood components transfused. In Chapter 3, I develop the first health-economic assessment of whole blood pathogen inactivation. The analysis is for Ghana and improves on prior blood safety assessments for sub-Saharan Africa by considering the likelihood and timing of clinical detection for chronic viral infections. In Chapter 4, I develop an optimization-based framework for identifying the optimal portfolio of blood safety interventions that overcomes some limitations of traditional cost-effectiveness analyses for blood safety. By applying this framework retrospectively to evaluate U.S. policies for Zika and West Nile virus, I show that the optimal policy can vary by geography, season, and year. Chapter 5 focuses on how frequently donors are allowed to give blood. I develop a machine learning-based decision model that tailors the inter-donation interval to each donor's risk of iron-related adverse outcomes to balance risks to donors against risks to the sufficiency of the blood supply. Together, these model-based analyses introduce novel methods and provide guidance for efficient and effective use of resources for blood safety.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Russell, William Alton |
|---|---|
| Degree supervisor | Brandeau, Margaret L |
| Thesis advisor | Brandeau, Margaret L |
| Thesis advisor | Goldhaber-Fiebert, Jeremy D |
| Thesis advisor | Owens, Douglas K |
| Degree committee member | Goldhaber-Fiebert, Jeremy D |
| Degree committee member | Owens, Douglas K |
| Associated with | Stanford University, Department of Management Science and Engineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | W. Alton Russell. |
|---|---|
| Note | Submitted to the Department of Management Science and Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2021 by William Alton Russell
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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