High-resolution small animal positron emission tomography system based on 3-D position-sensitive cadmium zinc telluride photon detectors
Abstract/Contents
- Abstract
- A description of the development of the world's first 1 mm resolution, adjustable field of view small animal positron emission tomography (PET) system is presented. The system uses cadmium zinc telluride (CZT) 3-D position sensitive photon detectors comprising CZT crystals measuring 40 mm x 40 mm x 5 mm, and metalized with a cross-strip electrode pattern. High photon sensitivity is achieved by adopting a box geometry for the field of view (FOV) (maximum extent of 100 mm x 100 mm x 80 mm) and an "edge-on" orientation of photon detectors, so that annihilation photons traverse a minimum of 40 mm through CZT. Based on both simulation and experimental investigations, a CZT photon detector was developed capable of resolving the 3-D position of individual photon interactions, making possible a range of new imaging algorithms for random coincidence rejection, line of response (LOR) placement, etc. Comprehensive characterization studies of single-crystal CZT photon detector demonstrated an (x, y, z) spatial resolution of 1 mm x 5 mm x ~0.5 mm and energy resolution of ~3% FWHM at 511 keV . This work further produced a full data acquisition (DAQ) chain for the PET system, comprising front-end boards based the RENA-3 ASIC capable of 50 Mbps data transmission, 48:1 fan-in boards connecting the front-end to the backplane, and a daisy chain backplane bus capable of 800 Mbps data transmission, connected to a DAQ computer via a 1 Gbps Ethernet connection. A software tool suite was developed to incorporate novel time and energy measurement calibration techniques and a new time coincident event identification algorithm for semiconductor photon detectors. The system's mechanical gantries and housings were fabricated, along with detector assembling and testing equipment. A prototype of the small animal PET system built to facilitate integration testing and troubleshooting yielded preliminary system-wide FWHM energy and coincidence time resolutions of 8.02 +/- 0.96% and 3.12 +/- 0.15 ns, respectively. Further system-level characterization experiments are on-going to validate these initial results, and subsequently, to assess the system's PSF, and reconstructed image resolution and contrast.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2014 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Gu, Yi |
|---|---|
| Associated with | Stanford University, Department of Electrical Engineering. |
| Primary advisor | Levin, Craig |
| Thesis advisor | Levin, Craig |
| Thesis advisor | Pelc, Norbert J |
| Thesis advisor | Widrow, Bernard, 1929- |
| Advisor | Pelc, Norbert J |
| Advisor | Widrow, Bernard, 1929- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Yi Gu. |
|---|---|
| Note | Submitted to the Department of Electrical Engineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2014. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2014 by Yi Gu
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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