Illuminated algorithms : expanding recordings of the neural code in space, time, and specificity
Abstract/Contents
- Abstract
- Our cognition, actions, and sensation are encoded by precise temporal signals distributed throughout the circuits of the nervous system. These algorithms give rise to our behavior and inspire the schema of artificial intelligence, but in most cases their implementation remains mysterious. In this thesis I present a diverse set of optical approaches that expand our capabilities for reading out neural function in space, time and specificity. I then apply these and other tools to map out the neural codes underlying learning and action selection in the normal and diseased brain. In the first half of this thesis, I detail work expanding the temporal resolution at which we can interrogate specific cell types in the brain using optical sensors of membrane voltage. This culminates with the development and application of a new methodology, termed TEMPO, that can record neural oscillations in specified cell-types deep in the brain in freely moving animals. In the second half of this thesis I discuss two studies detailing the ensemble neural codes used by the mammalian striatum. Here we applied tools for large-scale imaging of neuronal calcium activity at cellular resolution to powerfully test longstanding hypotheses about the nature of reward learning and parkinsonian neural dynamics. In all, these chapters reflect the coming of age of optical approaches for monitoring of neural dynamics and provide powerful examples of their potential for hypothesis driven and discovery science.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2015 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Marshall, Jesse |
|---|---|
| Associated with | Stanford University, Department of Physics. |
| Primary advisor | Schnitzer, Mark Jacob, 1970- |
| Thesis advisor | Schnitzer, Mark Jacob, 1970- |
| Thesis advisor | Chu, Steven |
| Thesis advisor | Ganguli, Surya, 1977- |
| Thesis advisor | Lin, Michael Z |
| Thesis advisor | Lecea, Luis de |
| Advisor | Chu, Steven |
| Advisor | Ganguli, Surya, 1977- |
| Advisor | Lin, Michael Z |
| Advisor | Lecea, Luis de |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Jesse Marshall. |
|---|---|
| Note | Submitted to the Department of Physics. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2015. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2015 by Jesse Duncan Marshall
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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