A mixed-reality system for breast surgical planning in the operating room : magnetic resonance imaging development and initial clinical evaluation
Abstract/Contents
- Abstract
- One quarter of women who undergo breast lumpectomy to treat early-stage breast cancer in the United States undergo a repeat surgery due to concerns that residual tumor was left behind. This has led to a significant increase in women choosing mastectomy operations in the United States. We have developed a mixed-reality system that projects a 3D rendering of images from a supine breast MRI onto a patient using the first-generation Microsoft HoloLens. The goal of this system is to reduce the number of repeated surgeries by improving surgeons' ability to appreciate tumor extent before--and ultimately during--the surgical procedure. We have taken several steps toward preparing this system for eventual clinical use, including: (1) development and preliminary evaluation of a supine dynamic contrast-enhanced breast MRI protocol to acquire images that more closely match the surgical position, (2) initial clinical evaluation of a mixed-reality system for breast surgical planning in the operating room in seven patients with palpable tumors, (3) a preliminary investigation of user depth perception on two commercially available mixed-reality headsets, and (4) development of proof-of-concept skin markings printed with magnetic ink that are visible both on MRI and by eye, which could be used to track deformation and improve registration to the patient with mixed reality. Although early results are promising that mixed-reality guidance can indeed provide information about tumor size and extent, it is critical but not straightforward to align the virtual content to the patient so that tumor location is accurately perceived. More work is needed to improve the registration by accounting for tissue deformations, as well as to properly calibrate the system for different users and optimize the display for arm's-length interaction. Nonetheless, this exciting new use for mixed reality has the potential to make tumor localization more intuitive for surgeons and to improve the lives of many patients
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Perkins, Stephanie Liu |
|---|---|
| Degree supervisor | Daniel, Bruce (Bruce Lewis) |
| Degree supervisor | Hargreaves, Brian Andrew |
| Thesis advisor | Daniel, Bruce (Bruce Lewis) |
| Thesis advisor | Hargreaves, Brian Andrew |
| Associated with | Stanford University, Department of Bioengineering |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Stephanie Liu Perkins |
|---|---|
| Note | Submitted to the Department of Bioengineering |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Stephanie Liu Perkins
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...