Engineering the nervous system
Abstract/Contents
- Abstract
- During differentiation of a totipotent zygote to multipotent progenitors and later to fully differentiation cells, morphogen gradients; and consequently, differential transcription factor expressions play important roles in directing the fates of different progenitor cells down the Waddington epigenetic slope into terminally differentiated cell types. It was later discovered that forced expression of some of those lineage-specifying transcription factors can be used to convert terminally differentiated cells to regain pluripotency or to other mature committed cell types. These discoveries open up a new avenue for the use of those cells for therapy or drug screening. Despite these novel discoveries, there are still concerns regarding the efficiency of direct conversion process and the identity of those converted cells. In this thesis, I will describe the background of induced neuronal cells, the functions of Ascl1 in induced neuronal reprogramming, a novel protocol to convert a readily available cell type into induced neuronal cells and the application of induced neuronal cells in disease modelling.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Ang, Cheen Euong |
|---|---|
| Degree supervisor | Wernig, Marius |
| Thesis advisor | Wernig, Marius |
| Thesis advisor | Bintu, Lacramioara |
| Thesis advisor | Chang, Howard Y. (Howard Yuan-Hao), 1972- |
| Degree committee member | Bintu, Lacramioara |
| Degree committee member | Chang, Howard Y. (Howard Yuan-Hao), 1972- |
| Associated with | Stanford University, Department of Bioengineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Cheen Euong Ang. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Cheen Euong Ang
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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