Coordination of junction biogenesis and epithelial integration during differentiation
Abstract/Contents
- Abstract
- The adult Drosophila midgut, like other epithelial tissues, undergoes dynamic self- renewal. The intestinal stem cells are the only mitotic cells in the midgut and they generate new cells, which are small and localize on the basal side of the epithelium. These daughter cells, enteroblasts, have to mature and integrate into the tissue as they differentiate into intestinal cells, called enterocytes. These new cells, as they integrate, have to form septate junctions with the surrounding fully differentiated intestinal cells to ensure the epithelial barrier is maintained. For my thesis work I have dedicated my research to investigating how the septate junction network is maintained during cellular differentiation. I have explored how a wide variety of cellular differentiation events such as establishment of apical polarity, integration into the tissue and expression of transcription factors, are coordinated with generation of septate junctions de novo in enteroblasts to ensure that the intestinal barrier is maintained during turnover.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Moreno-Roman, Paola |
|---|---|
| Degree supervisor | O'Brien, Lucy Erin, 1970- |
| Thesis advisor | O'Brien, Lucy Erin, 1970- |
| Thesis advisor | Axelrod, Jeffrey (Jeffrey David) |
| Thesis advisor | Bergmann, Dominique |
| Thesis advisor | Simon, Michael, (Biology professor) |
| Degree committee member | Axelrod, Jeffrey (Jeffrey David) |
| Degree committee member | Bergmann, Dominique |
| Degree committee member | Simon, Michael, (Biology professor) |
| Associated with | Stanford University, Department of Biology. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Paola Moreno-Roman. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Paola Moreno-Roman
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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