Human natural killer cell development in the age of single cell technologies
Abstract/Contents
- Abstract
- The study of hematopoiesis has been an ongoing effort to understand how the immune system develops. Throughout the course of history, the use of flow cytometry has enabled us to understand the development of multiple immune cell lineages. However, human Natural Killer (NK) cell development remains an elusive developmental population requiring further study to identify. NK cells have been characterized as cytotoxic innate lymphocytes that produce cytokines and clear viral infected and cancerous cells. Unlike other immune cell lineages, a comprehensive developmental pathway has yet to be identified. While developmental populations have been identified in human bone marrow (BM), these cells are rare and a larger pool of progenitors must exist due to their short lived nature. The use of single cell technologies presents an innovative approach to dissect the BM compartment and find novel precursors that will elucidate the development of NK cells. Utilizing these technologies allowed for the identification of a group of cells identified using transcriptional regulators key to NK cell development, ETS1 and ID2. Ultimately, our study expands our knowledge of new stages of NK lineage commitment for use in cancer immunotherapies.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Calderon, Ariel Alexander |
|---|---|
| Degree supervisor | Bendall, Sean, 1979- |
| Thesis advisor | Bendall, Sean, 1979- |
| Thesis advisor | Cleary, Michael L |
| Thesis advisor | Krams, Sheri Michele |
| Thesis advisor | Majeti, Ravindra, 1972- |
| Degree committee member | Cleary, Michael L |
| Degree committee member | Krams, Sheri Michele |
| Degree committee member | Majeti, Ravindra, 1972- |
| Associated with | Stanford University, Department of Microbiology and Immunology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Ariel Alexander Calderon. |
|---|---|
| Note | Submitted to the Department of Microbiology and Immunology. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/cy023by5893 |
Access conditions
- Copyright
- © 2022 by Ariel Alexander Calderon
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...