Myeloid cells in the tumor: a study on targeting myeloid-derived suppressor cells and activating macrophages for cancer immunotherapy
Abstract/Contents
- Abstract
- Colony stimulating factor-1 receptor (CSF1R) signaling is crucial for macrophage differentiation and survival. Inhibition of CSF1R through monoclonal antibodies and antagonists has been widely explored in preclinical studies due to its ability to deplete pro-tumorigenic tumor-associated macrophages. However, CSF1R inhibition has had limited clinical and therapeutic efficacy, necessitating the need for further investigation into the effects of CSF1R blockade on myelopoiesis in the tumor microenvironment. In this study, we report that deletion of CSF1R in an inducible knockout mouse model leads to the expansion of CXCR2+ granulocytic-myeloid derived suppressor cells (G-MDSCs) in both thioglycollate-induced peritonitis and tumorigenesis. Further, we demonstrate that targeting CXCR2+ G-MDSCs could increase macrophage programmed cell removal (PrCR), and combination with anti-CD47 monoclonal antibody treatment could serve as an effective therapeutic strategy for cancer treatment. Lastly, we begin a broader study on tumor clearance by macrophages through the lens of “eat me” signal calreticulin (Calr), ultimately revealing key molecular components of the mechanism of Calr secretion by macrophages for PrCR.
Description
| Type of resource | text |
|---|---|
| Publication date | November 14, 2022 |
Creators/Contributors
| Author | Zhang, Allison |
|---|---|
| Thesis advisor | Weissman, Irving |
| Thesis advisor | Majeti, Ravindra |
| Thesis advisor | Stearns, Tim |
| Degree granting institution | Stanford University, Department of Biology |
Subjects
| Subject | Biology |
|---|---|
| Subject | Macrophages |
| Subject | Myeloid-derived suppressor cells |
| Subject | Tumor Immunology |
| Subject | Calreticulin |
| Subject | CD47 |
| Genre | Text |
| Genre | Thesis |
Bibliographic information
Access conditions
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 4.0 International license (CC BY-NC).
Preferred citation
- Preferred citation
- Zhang, A. and Weissman, I. (2023). Myeloid cells in the tumor: a study on targeting myeloid-derived suppressor cells and activating macrophages for cancer immunotherapy. Stanford Digital Repository. Available at https://purl.stanford.edu/cs730yc9289. https://doi.org/10.25740/cs730yc9289.
Collection
Undergraduate Theses, Department of Biology, 2022-2023
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- Contact
- allisonzhang@stanford.edu
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