GENEticS of Insulin Sensitivity (GENESIS) Genome Wide Association Study results files
Abstract/Contents
- Abstract
Decreased insulin sensitivity, also referred to as insulin resistance (IR), is a fundamental abnormality in patients with type 2 diabetes and a risk factor for cardiovascular disease. While IR predisposition is heritable, the genetic basis remains largely unknown. The GENEticS of Insulin Sensitivity consortium conducted a genome-wide association study (GWAS) for direct measures of insulin sensitivity, such as euglycemic clamp or insulin suppression test, in 2,764 European individuals. The results deposited here represent the age, gender adjusted analyses as well as the age, gender and BMI adjusted analyses.
Please cite:
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.
Knowles JW, Xie W, Zhang Z, Chennamsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, Goodarzi MO, Carcamo-Orive I, Morris AP, Chen YD, Mäkinen VP, Ganna A, Mahajan A, Guo X, Abbasi F, Greenawalt DM, Lum P, Molony C, Lind L, Lindgren C, Raffel LJ, Tsao PS; RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) Consortium.; EUGENE (European Network on Functional Genomics of Type Diabetes) Study.; GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) Consortium.; SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and Insulin Resistance) Study., Schadt EE, Rotter JI, Sinaiko A, Reaven G, Yang X, Hsiung CA, Groop L, Cordell HJ, Laakso M, Hao K, Ingelsson E, Frayling TM, Weedon MN, Walker M, Quertermous T.
J Clin Invest. 2016 Jan;126(1):403.
PMID: 26727231
Description
| Type of resource | software, multimedia |
|---|---|
| Date created | 2008 - 2015 |
Creators/Contributors
| Author | Knowles, JW |
|---|---|
| Author | Xie, W |
| Author | Zhang, Z |
| Author | Chennamsetty, I |
| Author | Assimes, TL |
| Author | Paananen, J |
| Author | Hansson, O |
| Author | Pankow, J |
| Author | Goodarzi, MO |
| Author | Carcamo-Orive, I |
| Author | Morris, AP |
| Author | Chen, YD |
| Author | Mäkinen, VP |
| Author | Ganna, A |
| Author | Mahajan, A |
| Author | Guo, X |
| Author | Abbasi, F |
| Author | Greenawalt, DM |
| Author | Lum, P |
| Author | Molony, C |
| Author | Lind, L |
| Author | Lindgren, C |
| Author | Raffel, LJ |
| Author | Tsao, PS |
| Author | Rotter, JI |
| Author | Sinaiko, A |
| Author | Reaven, G |
| Author | Yang, X |
| Author | Hsiung, CA |
| Author | Groop, L |
| Author | Cordell, HJ |
| Author | Laakso, M |
| Author | Hao, K |
| Author | Ingelsson, E |
| Author | Frayling, TM |
| Author | Weedon, MN |
| Author | Walker, M |
| Author | Quertermous, T |
| Contributing author | RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) Consortium |
| Contributing author | EUGENE (European Network on Functional Genomics of Type Diabetes) Study |
| Contributing author | GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) Consortium |
| Contributing author | SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and Insulin Resistance) Study |
| Contributing author | Schadt, EE |
Subjects
| Subject | insulin resistance |
|---|---|
| Subject | GWAS |
| Subject | Stanford Department of Medicine |
| Subject | Stanford Cardiovascular Institute |
| Genre | Dataset |
Bibliographic information
| Related Publication | Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. Knowles JW, Xie W, Zhang Z, Chennamsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, Goodarzi MO, Carcamo-Orive I, Morris AP, Chen YD, Mäkinen VP, Ganna A, Mahajan A, Guo X, Abbasi F, Greenawalt DM, Lum P, Molony C, Lind L, Lindgren C, Raffel LJ, Tsao PS; RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) Consortium.; EUGENE (European Network on Functional Genomics of Type Diabetes) Study.; GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) Consortium.; SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and Insulin Resistance) Study., Schadt EE, Rotter JI, Sinaiko A, Reaven G, Yang X, Hsiung CA, Groop L, Cordell HJ, Laakso M, Hao K, Ingelsson E, Frayling TM, Weedon MN, Walker M, Quertermous T. J Clin Invest. 2016 Jan;126(1):403. https://doi.org/10.1172/JCI85921. No abstract available. https://www.ncbi.nlm.nih.gov/pubmed/26727231 |
|---|---|
| Related Publication | Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice. Chennamsetty I, Coronado M, Contrepois K, Keller MP, Carcamo-Orive I, Sandin J, Fajardo G, Whittle AJ, Fathzadeh M, Snyder M, Reaven G, Attie AD, Bernstein D, Quertermous T, Knowles JW. Cell Rep. 2016 Oct 4;17(2):527-540. https://doi.org/10.1016/j.celrep.2016.09.005. https://www.ncbi.nlm.nih.gov/pubmed/27705799 |
| Related Publication | Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, Häring H, Hansen T, Pedersen O, Smith U, Laakso M; MAGIC Investigators.; DIAGRAM Consortium.; GENESIS Consortium.; RISC Consortium., Dekker JM, Nolan JJ, Groop L, Ferrannini E, Adam KP, Gall WE, Frayling TM, Walker M. Diabetes. 2013 Jun;62(6):2141-50. https://doi.org/10.2337/db12-0876. https://www.ncbi.nlm.nih.gov/pubmed/23378610 |
| Related Publication | Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes. Fall T, Xie W, Poon W, Yaghootkar H, Mägi R; GENESIS Consortium., Knowles JW, Lyssenko V, Weedon M, Frayling TM, Ingelsson E.Diabetes. 2015 Jul;64(7):2676-84. https://doi.org/10.2337/db14-1710. https://www.ncbi.nlm.nih.gov/pubmed/25948681 |
| Related Publication | Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes. Yaghootkar H, Scott RA, White CC, Zhang W, Speliotes E, Munroe PB, Ehret GB, Bis JC, Fox CS, Walker M, Borecki IB, Knowles JW, Yerges-Armstrong L, Ohlsson C, Perry JR, Chambers JC, Kooner JS, Franceschini N, Langenberg C, Hivert MF, Dastani Z, Richards JB, Semple RK, Frayling TM. Diabetes. 2014 Dec;63(12):4369-77. https://doi.org/10.2337/db14-0318. https://www.ncbi.nlm.nih.gov/pubmed/25048195S |
| Location | https://purl.stanford.edu/ck072sq2582 |
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- Use and reproduction
- User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
Preferred citation
- Preferred Citation
- GENEticS of Insulin Sensitivity (GENESIS) Genome Wide Association Study results files. Stanford Digital Repository. Available at: http://purl.stanford.edu/ck072sq2582
Collection
Stanford Research Data
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- knowlej@stanford.edu
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