Dach1 regulates the specification of coronary artery endothelial cells
Abstract/Contents
- Abstract
- Cardiovascular disease (CVD) is the most common cause of death in the world and new treatments are needed to combat this disease. An unexplored approach to improving outcomes of patients suffering from CVD, is the expansion of artery networks on the heart. In the event that one section of a coronary artery is blocked, more abundant artery networks could compensate for the loss of one artery. However, the underlying genetic and molecular factors that regulate artery specification and growth are incompletely understood. Here, I use two approaches to advance our understanding of artery development. First, I show that upregulation of the transcriptional regulator, Dach1, in endothelial cells increases artery specification during embryonic development in mice. Second, in order to better understand the formation of collateral arteries, I used a comparative approach by investigating heart development in Cavia porcellus (guinea pig). I found that this high altitude rodent has numerous collateral arteries which form during embryonic development. Together, these studies provide insight into new strategies for increasing coronary artery abundance or changing coronary morphology. Identification and characterization of arterializing factors such as Dach1 or the purported guinea pig collateralizing regulators, could provide the basis for new artery based treatment option for people at risk of CVD.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2021; ©2021 |
| Publication date | 2021; 2021 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Raftrey, Brian Christopher |
|---|---|
| Degree supervisor | Red-Horse, Kristy |
| Thesis advisor | Red-Horse, Kristy |
| Thesis advisor | Dixon, Scott James, 1977- |
| Thesis advisor | Dunn, Alexander Robert |
| Degree committee member | Dixon, Scott James, 1977- |
| Degree committee member | Dunn, Alexander Robert |
| Associated with | Stanford University, Department of Biology |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Brian Raftrey. |
|---|---|
| Note | Submitted to the Department of Biology. |
| Thesis | Thesis Ph.D. Stanford University 2021. |
| Location | https://purl.stanford.edu/bp902br3190 |
Access conditions
- Copyright
- © 2021 by Brian Christopher Raftrey
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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