Dach1 regulates the specification of coronary artery endothelial cells

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Cardiovascular disease (CVD) is the most common cause of death in the world and new treatments are needed to combat this disease. An unexplored approach to improving outcomes of patients suffering from CVD, is the expansion of artery networks on the heart. In the event that one section of a coronary artery is blocked, more abundant artery networks could compensate for the loss of one artery. However, the underlying genetic and molecular factors that regulate artery specification and growth are incompletely understood. Here, I use two approaches to advance our understanding of artery development. First, I show that upregulation of the transcriptional regulator, Dach1, in endothelial cells increases artery specification during embryonic development in mice. Second, in order to better understand the formation of collateral arteries, I used a comparative approach by investigating heart development in Cavia porcellus (guinea pig). I found that this high altitude rodent has numerous collateral arteries which form during embryonic development. Together, these studies provide insight into new strategies for increasing coronary artery abundance or changing coronary morphology. Identification and characterization of arterializing factors such as Dach1 or the purported guinea pig collateralizing regulators, could provide the basis for new artery based treatment option for people at risk of CVD.


Type of resource text
Form electronic resource; remote; computer; online resource
Extent 1 online resource.
Place California
Place [Stanford, California]
Publisher [Stanford University]
Copyright date 2021; ©2021
Publication date 2021; 2021
Issuance monographic
Language English


Author Raftrey, Brian Christopher
Degree supervisor Red-Horse, Kristy
Thesis advisor Red-Horse, Kristy
Thesis advisor Dixon, Scott James, 1977-
Thesis advisor Dunn, Alexander Robert
Degree committee member Dixon, Scott James, 1977-
Degree committee member Dunn, Alexander Robert
Associated with Stanford University, Department of Biology


Genre Theses
Genre Text

Bibliographic information

Statement of responsibility Brian Raftrey.
Note Submitted to the Department of Biology.
Thesis Thesis Ph.D. Stanford University 2021.
Location https://purl.stanford.edu/bp902br3190

Access conditions

© 2021 by Brian Christopher Raftrey
This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).

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