Examining the role of neuron-glia signaling in the peripheral nervous system
Abstract/Contents
- Abstract
- The peripheral nervous system (PNS) is a complex interweave of neurons and glial cells, both of which are critical for information transfer and processing. Electrical signaling in the PNS relies, in part, on a diverse family of membrane proteins known as ion channels that are predominantly expressed in primary neurons of the PNS. Here, we demonstrate that Schwann cells, the most abundant glia in the PNS, regulate the excitability of dorsal root ganglia (DRGs), the somatosensory neuron of the PNS, through secretion of prostaglandin E2 (PGE2). As our work shows, this low molecular weight signaling agent acts on DRGs to alter voltage-gated sodium channel (NaV) expression. Experiments to understand the underlying mechanism by which PGE2 regulates action potential firing in DRGs and whether voltage-gated potassium channels (KVs) are modulated by PGE2 are also presented.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2022; ©2022 |
| Publication date | 2022; 2022 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Elvira, Pablo Daniel |
|---|---|
| Degree supervisor | Du Bois, Justin |
| Thesis advisor | Du Bois, Justin |
| Thesis advisor | Bertozzi, Carolyn R, 1966- |
| Thesis advisor | Khosla, Chaitan, 1964- |
| Degree committee member | Bertozzi, Carolyn R, 1966- |
| Degree committee member | Khosla, Chaitan, 1964- |
| Associated with | Stanford University, Department of Chemistry |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Pablo Daniel Elvira. |
|---|---|
| Note | Submitted to the Department of Chemistry. |
| Thesis | Thesis Ph.D. Stanford University 2022. |
| Location | https://purl.stanford.edu/bm677dy7491 |
Access conditions
- Copyright
- © 2022 by Pablo Daniel Elvira
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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