Cell-cycle control in aging, cancer, and homeostasis
Abstract/Contents
- Abstract
- Mammalian development and homeostasis require precise control of cellular proliferation. Excess cellular proliferation causes cancer, while insufficient cellular proliferation is associated with aging. The work presented herein details specific mechanisms of cell-cycle regulation and how they contribute to homeostasis, aging, and cancer. The first study reveals how a lack of coordination between major proliferation signaling pathways contributes to cellular aging. In the second study, an unexpected mechanism of action is revealed for an important class of cancer therapeutics targeting the core cell-cycle machinery. The final study describes how cells navigate the inherently stressful process of genome duplication. Taken together, these studies contribute novel insights to our understanding of the mechanisms and importance of cell-cycle regulation
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Daigh, Leighton Harrison |
|---|---|
| Degree supervisor | Meyer, Tobias |
| Thesis advisor | Meyer, Tobias |
| Thesis advisor | Ferrell, James Ellsworth |
| Thesis advisor | Sage, Julien |
| Degree committee member | Ferrell, James Ellsworth |
| Degree committee member | Sage, Julien |
| Associated with | Stanford University, Department of Chemical and Systems Biology. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Leighton H. Daigh |
|---|---|
| Note | Submitted to the Department of Chemical and Systems Biology |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Leighton Harrison Daigh
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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