IgG Autoantibodies Induced by COVID-19 and Other Respiratory Disease
Abstract/Contents
- Abstract
- Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), was first identified in December of 2019 and has since spread worldwide, leading to the current pandemic. Symptoms of COVID-19 usually include fever, cough, fatigue, respiratory difficulties, as well as loss of smell and taste. However, the disease is associated with a wide range of clinical manifestations, including hallmarks of autoimmunity and autoantibody production. My lab developed three different protein arrays to measure IgG autoantibodies associated with Connective Tissue Diseases (CTDs), Anti-Cytokine Antibodies (ACA), and anti-viral antibody responses in 147 hospitalized COVID-19 patients from three different centers. Autoantibodies in patients with other respiratory diseases, severe Influenza and Acute respiratory distress syndrome (ARDS), from two other centers were also measured. Overall, autoantibodies were identified in approximately 50% of COVID-19 patients, but in <15% of healthy controls. Anti-nuclear antibodies (ANA) were observed in ~25% of patients. In comparison, ANAs were observed in 33% and 22% of severe Influenza and ARDS patients, respectively. For COVID-19 patients, autoantibodies tracked with longitudinal development of IgG antibodies that recognized SARS-CoV-2 structural proteins such as S1, S2, M, N and a subset of non-structural proteins, but not proteins from influenza, seasonal coronaviruses or other pathogenic viruses. I conclude that SARS-CoV-2 causes development of new-onset IgG autoantibodies in a significant proportion of hospitalized COVID-19 patients and are positively correlated with immune responses to SARS-CoV-2 proteins. However, severe Influenza and ARDS induce fewer autoantibodies than COVID-19.
Description
| Type of resource | text |
|---|---|
| Date created | June 2021 |
| Date modified | December 5, 2022 |
| Publication date | May 4, 2022 |
Creators/Contributors
| Author | Feng, Allan |
|---|---|
| Degree granting institution | Stanford University, Department of Biology, 2021 |
| Thesis advisor | Utz, Paul |
| Thesis advisor | Morrison, Ashby |
Subjects
| Subject | Biology |
|---|---|
| Subject | Immunology |
| Subject | COVID-19 |
| Genre | Text |
| Genre | Thesis |
Bibliographic information
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- User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
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- This work is licensed under a Creative Commons Attribution Share Alike 3.0 Unported license (CC BY-SA).
Preferred citation
- Preferred citation
- Feng, Allan, Utz, Paul and Morrison, Ashby. (2021). IgG Autoantibodies Induced by COVID-19 and Other Respiratory Disease. Stanford Digital Repository. Available at: https://purl.stanford.edu/bg674bs3393
Collection
Undergraduate Theses, Department of Biology, 2020-2021
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- afeng1@stanford.edu
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