History and context-dependent modulation of rodent sensory processing
Abstract/Contents
- Abstract
- This thesis consists of three separate chapters, representing my journey from engineer to neuroscientist, and my PhD thesis. Two are completed papers, and each project is self-contained with relevant introductory material and context in the respective introductions, while the general introduction provides a brief orientation to my work in the general context of systems neuroscience. These projects span sensory systems neuroscience from spinal cord neurobiology to cortex and computation. In the first chapter I present a surgical technique to implant a cannula into the vertebral column of mice, allowing optogenetic access to spinal sensory neurons in the dorsal horn. In the second chapter, I analyze visual cortex calcium imaging data from the Allen Institute Brain observatory during free locomotion behavior. This analysis reveals that lower background noise during locomotion might be responsible for the increased encoding accuracy during locomotion (as opposed to increased firing rates). In the last chapter, I introduce a rodent decision-making task intended to allow parametric control both of the animals' expectation of the sensory stimuli as well as the noise in the stimuli
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2020; ©2020 |
| Publication date | 2020; 2020 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Christensen, Amelia J |
|---|---|
| Degree supervisor | Schnitzer, Mark Jacob, 1970- |
| Thesis advisor | Schnitzer, Mark Jacob, 1970- |
| Thesis advisor | Shenoy, Krishna V. (Krishna Vaughn) |
| Thesis advisor | Solgaard, Olav |
| Degree committee member | Shenoy, Krishna V. (Krishna Vaughn) |
| Degree committee member | Solgaard, Olav |
| Associated with | Stanford University, Department of Electrical Engineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Amelia Christensen |
|---|---|
| Note | Submitted to the Department of Electrical Engineering |
| Thesis | Thesis Ph.D. Stanford University 2020 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2020 by Amelia J Christensen
- License
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
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