Treating neuroinflammatory diseases via pharmacological modulation of microglia
Abstract/Contents
- Abstract
- Microglia are the resident tissue macrophages of the central nervous system (CNS) parenchyma. While less than 20% of the cellular composition of the CNS is made up of by microglia, they play many roles in the CNS ranging from tissue remodeling, maintenance and repair to protecting the CNS against insults, both foreign- and self-derived. It is not surprising that microglia dysfunction has been shown to contribute to major neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Multiple Sclerosis (MS) as well ass lesser-known diseases such as Nasu-Hakola disease. Unfortunately, the ability to modulate microglia to beneficially modify neurodegenerative diseases remains limited. This dissertation illustrates how an antiviral and a hypertension medication ameliorate disease in animal models of neuroinflammation and neurodegeneration by modulating the cellular and molecular functions of microglia.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2012 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Ding, Zhaoqing | |
|---|---|---|
| Associated with | Stanford University, Program in Immunology. | |
| Primary advisor | Wyss-Coray, Anton | |
| Thesis advisor | Wyss-Coray, Anton | |
| Thesis advisor | Buckwalter, Marion | |
| Thesis advisor | Chawla, Ajay | |
| Thesis advisor | Steinman, Lawrence | |
| Advisor | Buckwalter, Marion | |
| Advisor | Chawla, Ajay | |
| Advisor | Steinman, Lawrence |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Zhaoqing Ding. |
|---|---|
| Note | Submitted to the Program in Immunology. |
| Thesis | Ph.D. Stanford University 2012 |
| Location | electronic resource |
Access conditions
- Copyright
- © 2012 by Zhaoqing Ding
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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