Tumor-induced suppression of host immunity
Abstract/Contents
- Abstract
- Interactions between the immune system and cancer cells have long been appreciated to play a role in regulating tumor progression. Accumulating evidence have pointed to the phenomenon of cancer immunosurveillance, where the host immune system is able to inhibit or eradicate malignant tumor cells. Conversely, research has also revealed multiple mechanisms by which tumor cells can suppress and overcome host immunity. In this thesis, I examine mechanisms by which tumor-initiating cells in head and neck cancer can regulate their immunogenicity and selectively evade the host immune response. I also examine how natural killer (NK) cells become functionally exhausted during tumor progression, and identify markers of exhaustion that can be targeted by antibody blockade.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2016 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Lee, Yunqin | |
|---|---|---|
| Associated with | Stanford University, Program in Immunology. | |
| Primary advisor | Sunwoo, John B | |
| Thesis advisor | Sunwoo, John B | |
| Thesis advisor | Engleman, Edgar G | |
| Thesis advisor | Krams, Sheri Michele | |
| Thesis advisor | Majeti, Ravindra, 1972- | |
| Advisor | Engleman, Edgar G | |
| Advisor | Krams, Sheri Michele | |
| Advisor | Majeti, Ravindra, 1972- |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Yunqin Lee. |
|---|---|
| Note | Submitted to the Program in Immunology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2016. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2016 by Yunqin Lee
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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