Axl as a therapeutic target in metastatic ovarian cancer
Abstract/Contents
- Abstract
- ABSTRACT Axl, Sky, and Mer receptor tyrosine kinases (RTKs) are increasingly implicated in a host of cellular responses including cell survival, proliferation, migration, phagocytosis, chemoresistance, and epithelial-mesenchymal transition (EMT). Furthermore, the Gas6/AXL system is implicated in several types of human cancer as well as inflammatory, autoimmune, vascular and kidney diseases. Since the discovery of Gas6/AXL in 1988 in chronic myelogenous leukemia, many more cancers have been found to express AXL. In chapter 1, I will describe my contribution to the field that includes identifying the role of AXL in metastatic ovarian cancer and validating the therapeutic target in ovarian cancer. In the second chapter, I have investigated the role of AXL in chemoresistance in ovarian cancer. Within the past decade, AXL crosstalk has emerged as a dominant pathway for ligand-independent activation. With the recent identification of AXL as an important factor in mediating tyrosine kinase inhibitor resistance, understanding this cross-talk is important. There has been a recent report of c-MET and AXL cross-talk in breast cancer. c-MET has become a potential target for cancer therapy with numerous clinical trials using c-MET inhibitors as monotherapy or in combination with other targeted agents or chemotherapy. I have further explored this cross-talk in ovarian cancer. In my final chapter, I have identified AXL expression in ovarian cancer tumors formed in a conditional genetically modified invasive ovarian cancer mouse model. In the future, AXL therapy should be further investigated in patients with metastatic ovarian cancer.
Description
Type of resource | text |
---|---|
Form | electronic; electronic resource; remote |
Extent | 1 online resource. |
Publication date | 2013 |
Issuance | monographic |
Language | English |
Creators/Contributors
Associated with | Fuh, Katherine Cynthia | |
---|---|---|
Associated with | Stanford University, Cancer Biology Program. | |
Primary advisor | Giaccia, Amato J | |
Thesis advisor | Giaccia, Amato J | |
Thesis advisor | Cochran, Jennifer R | |
Thesis advisor | Hu, Mickey | |
Thesis advisor | Sweet-Cordero, Eric | |
Advisor | Cochran, Jennifer R | |
Advisor | Hu, Mickey | |
Advisor | Sweet-Cordero, Eric |
Subjects
Genre | Theses |
---|
Bibliographic information
Statement of responsibility | Katherine Cynthia Fuh. |
---|---|
Note | Submitted to the Cancer Biology Program. |
Thesis | Thesis (Ph.D.)--Stanford University, 2013. |
Location | electronic resource |
Access conditions
- Copyright
- © 2013 by Katherine Cynthia Fuh
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...