mSWI/SNF (BAF) and Topoisomerase II alpha synergize in the regulation of chromatin accessibility, cancer, and neurologic disease
Abstract/Contents
- Abstract
- Mammalian BAF (also known as mSWI/SNF) ATP-dependent chromatin remodeling complexes modulate chromatin and nucleosome structure to regulate chromatin processes such as transcription and DNA replication. Recent sequencing studies have implicated BAF complexes in a variety of human diseases, including a wide variety of neurodevelopmental syndromes and up to 20% of cancers. We have demonstrated that these complexes promote normal cell cycling by facilitating the activity and recruitment of Topoisomerase II [alpha] (TOP2A). We have also shown that BAF complexes mediate chromatin accessibility primarily at distal regulatory regions. Finally, we provide evidence that BAF complexes, along with Topoisomerase II [beta], regulate depolarization-activated ASD-related gene networks. These data illuminate the molecular mechanisms of BAF complexes in both normal and disease settings.
Description
Type of resource | text |
---|---|
Form | electronic; electronic resource; remote |
Extent | 1 online resource. |
Publication date | 2014 |
Issuance | monographic |
Language | English |
Creators/Contributors
Associated with | Miller, Erik Lehman | |
---|---|---|
Associated with | Stanford University, Department of Genetics. | |
Primary advisor | Crabtree, Gerald R | |
Thesis advisor | Crabtree, Gerald R | |
Thesis advisor | Baker, Julie, (Professor of genetics) | |
Thesis advisor | Sidow, Arend | |
Thesis advisor | Snyder, Michael, Ph. D | |
Advisor | Baker, Julie, (Professor of genetics) | |
Advisor | Sidow, Arend | |
Advisor | Snyder, Michael, Ph. D |
Subjects
Genre | Theses |
---|
Bibliographic information
Statement of responsibility | Erik Lehman Miller. |
---|---|
Note | Submitted to the Department of Genetics. |
Thesis | Thesis (Ph.D.)--Stanford University, 2014. |
Location | electronic resource |
Access conditions
- Copyright
- © 2014 by Erik Miller
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Also listed in
Loading usage metrics...