Microsystems to study the mechanobiology of cell adhesion
Abstract/Contents
- Abstract
- Adherent cell functions can be altered by mechanical stimuli through cytoskeleton remodeling and cell-cell junction disruption. Thus, a better understanding of the mechanical response of adherent cells is crucial to the design of pharmacological therapies for cancers and skin blistering diseases. However, a lack of reliable tools to apply mechanical stimuli and probe the cellular response has limited research on the effects of varying strains on adherent cells. Therefore, I develop systems to probe cellular mechanics using microfabrication technology with soft materials specifically designed to exert controlled strain on adherent cells and probe their mechanical response.
Description
Type of resource | text |
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Form | electronic; electronic resource; remote |
Extent | 1 online resource. |
Publication date | 2015 |
Issuance | monographic |
Language | English |
Creators/Contributors
Associated with | Sim, Joo Yong | |
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Associated with | Stanford University, Department of Mechanical Engineering. | |
Primary advisor | Pruitt, Beth | |
Thesis advisor | Pruitt, Beth | |
Thesis advisor | Dunn, Alexander Robert | |
Thesis advisor | Nelson, William | |
Advisor | Dunn, Alexander Robert | |
Advisor | Nelson, William |
Subjects
Genre | Theses |
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Bibliographic information
Statement of responsibility | Joo Yong Sim. |
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Note | Submitted to the Department of Mechanical Engineering. |
Thesis | Thesis (Ph.D.)--Stanford University, 2015. |
Location | electronic resource |
Access conditions
- Copyright
- © 2015 by Joo Yong Sim
- License
- This work is licensed under a Creative Commons Attribution 3.0 Unported license (CC BY).
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