Measuring, mitigating, and modeling the impact of skin treatments and solar exposure on the barrier function of human stratum corneum
Abstract/Contents
- Abstract
- The biomechanical behavior of human stratum corneum (SC), the outermost layer of skin, is critical for its large role in providing the barrier function of human skin. The degradation of the SC's natural biomechanical function can thus lead to painful skin conditions such as atopic dermatitis, exacerbated wounds and scarring, and reduced compatibility of wearable electronic devices. However, the effects of synergistic environmental exposures and most topical cosmetic treatments on key mechanical properties such as stress and intercellular cohesion in the SC have not been previously quantified and their mechanisms of action remain poorly understood. Consequently, the first step necessary to make informed designs of protective or stress mitigating treatments is to elucidate the underlying mechanism in the SC of mechanical stress, the driving force for damage to the skin barrier function. As a result, the critical connection between water volume loss during drying and stress development is introduced. The effect of treatment molecules, such as emollients and moisturizers, on macroscopic stress and cohesion is then analyzed through the presented framework, thus significantly clarifying the treatment characteristics necessary to mitigate SC damage. After establishing the role of treatments to protect the skin, the impact of simultaneous ultraviolet (UV) light and heat exposure (to approximate infrared radiation) is quantified to demonstrate the ability of synergistic solar damage processes in the SC to enhance stress and reduce intercellular cohesion, thus increasing the risk of barrier function degradation. In this context, the efficacies of UVB absorbing molecules (and their carrier vehicle) to protect the SC biomechanical properties from UV damage is investigated. This results in a new understanding of multiple mechanisms (i.e. water loss, treatment molecule diffusion, environmental damage, photoabsorber protection) that may simultaneously affect SC biomechanics, a vital step towards the successful protection and maintenance of a healthy skin barrier function.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Berkey, Christopher Andrew | |
|---|---|---|
| Degree supervisor | Dauskardt, R. H. (Reinhold H.) | |
| Thesis advisor | Dauskardt, R. H. (Reinhold H.) | |
| Thesis advisor | Appel, Eric (Eric Andrew) | |
| Thesis advisor | Chaudhuri, Ovijit | |
| Degree committee member | Appel, Eric (Eric Andrew) | |
| Degree committee member | Chaudhuri, Ovijit | |
| Associated with | Stanford University, Department of Materials Science and Engineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Christopher A. Berkey. |
|---|---|
| Note | Submitted to the Department of Materials Science and Engineering. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Christopher Andrew Berkey
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