Ultrasound neuromodulation : optimization, mechanisms, and confounds
Abstract/Contents
- Abstract
- Ultrasound neuromodulation has recently gained attention as a novel brain stimulation technology. There are several obstacles that ultrasound neuromodulation faces before the technology is ready for clinical use, including the need for optimizing ultrasound parameters, understanding of the unknown mechanism, and characterizing potential stimulation confounds. In this dissertation, I will present research addressing several of these challenges. I investigated the frequency dependence of ultrasound neuromodulation in the mouse model, with results suggesting an inherent tradeoff between spatial focusing and stimulation efficacy. In collaboration with the Baccus lab, we found evidence supporting a radiation force hypothesis for the mechanism of neuromodulation. Finally, I hypothesized that ultrasound was causing stimulation confounds via either the vestibular system or the tactile sensory system. Experiments using a vestibulotoxin mouse model suggest that stimulation of the vestibular system may play a significant role in ultrasound-elicited motor responses. Future work is still needed to address questions regarding optimal parameters, the mechanism, and stimulation confounds as ultrasound neuromodulation techniques mature.
Description
| Type of resource | text |
|---|---|
| Form | electronic resource; remote; computer; online resource |
| Extent | 1 online resource. |
| Place | California |
| Place | [Stanford, California] |
| Publisher | [Stanford University] |
| Copyright date | 2019; ©2019 |
| Publication date | 2019; 2019 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Author | Ye, Patrick Peiyong | |
|---|---|---|
| Degree supervisor | Pauly, Kim Butts (Kim Rosemary Butts) | |
| Thesis advisor | Pauly, Kim Butts (Kim Rosemary Butts) | |
| Thesis advisor | Baccus, Stephen A | |
| Thesis advisor | Pelc, Norbert J | |
| Degree committee member | Baccus, Stephen A | |
| Degree committee member | Pelc, Norbert J | |
| Associated with | Stanford University, Department of Bioengineering. |
Subjects
| Genre | Theses |
|---|---|
| Genre | Text |
Bibliographic information
| Statement of responsibility | Patrick Peiyong Ye. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis Ph.D. Stanford University 2019. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2019 by Patrick Peiyong Ye
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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