Genomic and epigenomic evolution in human acute myeloid leukemia
Abstract/Contents
- Abstract
- Cancer has been shown to result from the sequential acquisition of genetic alterations in a single lineage of cells. In leukemia, increasing evidence has supported the idea that this accumulation of mutations occurs in self-renewing hematopoietic stem cells (HSCs). These HSCs, containing some, but not all, leukemia-specific mutations have been termed pre-leukemic. This work charts the discovery and characterization of these pre-leukemic HSCs and provides key insights into the extent to which they contribute to leukemogenesis. The studies described here have elucidated patterns in mutation acquisition in leukemia, demonstrated resistance of pre-leukemic cells to standard induction chemotherapy, and identified these pre-leukemic cells as a putative reservoir for the generation of relapsed disease. When combined with decades of research on clonal evolution in leukemia, mouse models of leukemogenesis, and recent massively parallel sequencing-based studies of primary patient leukemia, these studies of pre-leukemic HSCs begin to piece together the evolutionary puzzle of leukemogenesis. These results have broad implications for leukemia treatment, targeted therapies, minimal residual disease monitoring, and early detection screening.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2015 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Corces-Zimmerman, M. Ryan | |
|---|---|---|
| Associated with | Stanford University, Program of Cancer Biology. | |
| Primary advisor | Majeti, Ravindra, 1972- | |
| Thesis advisor | Majeti, Ravindra, 1972- | |
| Thesis advisor | Alizadeh, Ash | |
| Thesis advisor | Sage, Julien | |
| Thesis advisor | Weissman, Irving L | |
| Advisor | Alizadeh, Ash | |
| Advisor | Sage, Julien | |
| Advisor | Weissman, Irving L |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | M. Ryan Corces-Zimmerman. |
|---|---|
| Note | Submitted to the Program of Cancer Biology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2015. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2015 by Michael Ryan Corces-Zimmerman
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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