Novel approaches to the visualization of cell specific gene expression patterns
Abstract/Contents
- Abstract
- The fate of a cell is largely determined by the unique patterns of gene expression found within it. Complex biological machinery exists within each cell to manipulate chromatin state, and ultimately control gene expression. Developmental processes such as cellular differentiation require very specific chemical signals and environmental conditions. These serve as triggers to put the chromatin modification schemes that produce the resultant patterns of differential gene expression into action, leading to the formation of the cell type of interest. My thesis work is an in depth study of the link between chromatin modification, gene expression, and the unique genetic signatures that characterize distinct cells on unicellular and multi-cellular levels. On the multi-cellular level, I have examined histone modification patterns for their effects on gene activation and repression during human embryonic stem cell differentiation. On the unicellular level, I have worked with a variety of cell types to ascertain the degree of individuality that exists between single members of relatively homogenous cell groups while simultaneously looking for housekeeping gene expression signatures that can be used to classify each cell type into a unique group. To further elucidate the patterns of gene expression found within cell groups and the single cells that comprise them, I have worked to develop new computational methods that produce visual aids to elucidate gene expression signatures of single cells and cell groups.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2011 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Oyolu, Chuba Benson Odimegwu | |
|---|---|---|
| Associated with | Stanford University, Department of Bioengineering. | |
| Primary advisor | Baker, Julie, (Professor of genetics) | |
| Thesis advisor | Baker, Julie, (Professor of genetics) | |
| Thesis advisor | Altman, Russ | |
| Thesis advisor | Deisseroth, Karl | |
| Advisor | Altman, Russ | |
| Advisor | Deisseroth, Karl |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Chuba Benson Oyolu. |
|---|---|
| Note | Submitted to the Department of Bioengineering. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2011. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2011 by Chuba Benson Odimegwu Oyolu
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