Mitochondrial association : a new window of opportunity for toxoplasma gondii?
Abstract/Contents
- Abstract
- Protozoan and prokaryotic pathogens are able to recruit mitochondria to the vacuoles in which they grow (Friis, 1972; Horwitz, 1983), in mammalian and protozoan cells. The functional significance of the recruitment and association of this phenomenon in Toxoplasma-infected cells has been a subject of speculation since it was first described in the early 1970s (Jones et al., 1972). Previous work has proposed Toxoplasma gondii rhoptry protein 2 (Sinai and Joiner, 2001) as the physical link that tethers host mitochondria to the parasitophorous vacuole and conventional wisdom since has suggested that mitochondrial recruitment served a nutritional function supplementary to the parasite. A recent analysis of the ROP2 structure raised questions about this model ((Labesse et al., 2009; Reese and Boothroyd, 2009). Chapter II describes the effect of deleting ROP2 on mitochondrial association while Chapter III describes the identification of a novel mediator of mitochondrial association, Mitochondrial association factor I (MAF1) and experiments that attempt to answer the role of this remarkable phenomenon in the host-pathogen interaction. Chapter IV describes a project undertaken to determine the impact of Toxoplasma gondii infection in humans acutely and chronically infected in different geographical regions. Chapter V concludes with a discussion of future directions for further characterization of host mitochondrial association in the host response to microbial infection.
Description
| Type of resource | text |
|---|---|
| Form | electronic; electronic resource; remote |
| Extent | 1 online resource. |
| Publication date | 2013 |
| Issuance | monographic |
| Language | English |
Creators/Contributors
| Associated with | Pernas, Lena | |
|---|---|---|
| Associated with | Stanford University, Department of Microbiology and Immunology. | |
| Primary advisor | Boothroyd, John C | |
| Thesis advisor | Boothroyd, John C | |
| Thesis advisor | Cyert, Martha S, 1958- | |
| Thesis advisor | Davis, Mark M | |
| Thesis advisor | Singh, Upinder, (Physician) | |
| Advisor | Cyert, Martha S, 1958- | |
| Advisor | Davis, Mark M | |
| Advisor | Singh, Upinder, (Physician) |
Subjects
| Genre | Theses |
|---|
Bibliographic information
| Statement of responsibility | Lena Pernas. |
|---|---|
| Note | Submitted to the Department of Microbiology and Immunology. |
| Thesis | Thesis (Ph.D.)--Stanford University, 2013. |
| Location | electronic resource |
Access conditions
- Copyright
- © 2013 by Lena Farah Pernas
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
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