Serial section TEM of touch receptor neurons from transgenic mec-12 putative null expressing mec-12 K40R
Abstract/Contents
- Abstract
- Serial section EM data with the following results. Reminiscent of the microtubule phenotype observed in mec-17;atat-2 double mutants, mec-12 null mutant TRNs expressing MEC-12(K40R) harbored polymorphic microtubules. Because this substitution replaces lysine 40 with a positively charged residue that cannot be acetylated, this finding suggests that the post- translational modification per se is crucial for the formation or stability of 15-pf microtubules.
Description
Type of resource | software, multimedia |
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Date created | 2012 |
Creators/Contributors
Creator | Cueva, Juan G. | |
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Principal investigator | Goodman, Miriam B. |
Subjects
Subject | electron microscopy |
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Subject | Caenorhabditis elegans |
Subject | neurons |
Subject | mechanosensation |
Subject | touch |
Subject | microtubules |
Subject | alpha tubulin |
Subject | alpha tubulin acetyltransferase |
Subject | transgenic |
Genre | Dataset |
Bibliographic information
Related Publication | Juan G. Cueva, Jen Hsin, Kerwyn Casey Huang, and Miriam B. Goodman. (2012). Posttranslational Acetylation of alpha-tubulin Constrains Protofilament Number in Native Microtubules. Current Biology 22, 1066-1074. http://dx.doi.org/10.1016/j.cub.2012.05.012 |
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Location | https://purl.stanford.edu/bz772xw6009 |
Access conditions
- Use and reproduction
- User agrees that, where applicable, content will not be used to identify or to otherwise infringe the privacy or confidentiality rights of individuals. Content distributed via the Stanford Digital Repository may be subject to additional license and use restrictions applied by the depositor.
- License
- This work is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported license (CC BY-NC).
Preferred citation
- Preferred Citation
- Cueva, Juan G. and Goodman, Miriam B. (2012). Serial section TEM of touch receptor neurons from transgenic mec-12 putative null expressing mec-12 K40R. Stanford Digital Repository. Available at: http://purl.stanford.edu/bz772xw6009
Collection
Serial section electron microscopy data for "Posttranslational acetylation of alpha tubulin constrains protofilament number in native microtubules"
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- Contact
- mbgoodman@stanford.edu
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